In a collaborative study published Feb. 9, 2009, in the Proceedings of the National Academy of Sciences (PNAS), scientists performed a genome-wide expression analysis comparing highly enriched normal blood stem cells and leukemic stem cells, and identified several new pathways that have a key role in cancer development.

Many scientists believe the best way to eradicate cancer is to find therapies that target cancer's stem cells, the cells thought to be responsible for maintaining the disease. Most cancer treatments today fail to attack cancer at its root, which is why the disease can recur despite aggressive therapy.

Before the development of cancer stem cell therapies can take place, however, scientists must improve our understanding of the similarities and differences between biological networks active in leukemic stem cells and their normal cell counterparts

The PNAS paper showed that by using modern microarray technology, scientists could reveal a swath of stem-cell pathways - some of which were already well known and others not previously implicated in leukemia and other cancers…